Effects of aqueous extract from Silybum marianum  on adenosine deaminase activity in cancerous and  noncancerous human gastric and colon tissues

Bahadir Ozturk; Ender Hilmi Kocaoğlu; Zahide Esra Durak

Articles

Abstract

Pharmacognosy Magazine,2015,11,41,143-146.

DOI:10.4103/0973-1296.149729

Published:January 2015

Type:Original Article

Authors:

Author(s) affiliations:

Bahadır Öztürk, Ender Hilmi Kocaoğlu1 , Zahide Esra Durak2

Department of Medical Biochemistry, Faculty of Medicine, Selcuk University, Konya,1 Department of Surgical Oncology, Faculty of Medicine, Ankara University,

2 Central Research Laboratory, Ordu University, Ordu, Turkey

Abstract:

Objective: Investigation of possible effects of Silybum marianum extract (SME) on adenosine deaminase (ADA) activity in cancerous and noncancerous human gastric and colon tissues to obtain information about possible mechanism of anticancer action of S. marianum. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues removed from patients by surgical operations were used in the studies. The extract was prepared in distilled water. Before and after treatment with the extract, ADA activities in the samples were measured. Results: ADA activity was found to be lowered significantly in cancerous gastric tissues but not in noncancerous gastric tissues after treatment with the SME. In the colon tissues, ADA activities were however found to increase after the treatment of SME. Conclusion: Our results suggest that the aqueous extract from S. marianum inhibits ADA activity in cancerous gastric tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA might also play a part in the anticancer properties of the S. marianum.