Study the relative effect of spironolactone and different solvent extract of Tibulus terrestrison urolithiatic rats

Hyperoxaluria is the foremost initiating cause for urolithiasis in renal cavities, where urolithiasis is a common urinary tract disorder. There is much expectation of finding active anti-urolithiatic compounds from indigenous plant as there are still uses in therapeutic despite the progress in conventional chemistry and pharmacology in producing effecting drugs. Most patients still have to undergo surgery to get rid of painful disease. In our present study on anti-urolithiatic agents from plants which was compared with synthetic chemical substance. As we have selected the sequential extracts of Tribulus terrestris with pet ether, chloroform, alcohol and water and compared the activity with the synthetic steroidal drug spironolactone which was used on the lithiatic induced rats and estimated the effect of the extract by doing the invo and invitro analysis alongside by histopathological studies and found the ethanolic extract of the drug was found to be effective than other treatment.