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  Indian J Med Microbiol
 

Figure 6: (a) Effect of FCO on thymus histopathology in mice (400×). A: blank control group; B: immunosuppressed group, the thymocytes of cortex decreased, in which the thymocytes were broken and the interlobular septum was widened (arrow); C: positive control group, the cortical thymocytes were dense and the thymic corpuscle was intact, whereas the interlobular septum was widened (arrow); D: FCO low-dose group, fewer thymocytes in cortex and thymocyte fragments (arrow); E: FCO medium-dose group, the thymocytes of cortex and the thymic corpuscle were normal (arrow); F: FCO high-dose group, the boundary between cortex and medulla was significant with intact thymic corpuscle structure and clear vein structure (arrow). All the pictures are ×400 magnification. (b) Effect of FCO on spleen histopathology in mice (400×). A: blank control group; B: immunosuppressed group, LYM decreased with disordered trabecular structure and hemorrhagic spots were found (arrow); C: positive control group, the trabecula were normal (arrow); D: FCO low-dose group, the LYM in white pulp had a decreased number (arrow); E: FCO medium-dose group, the ellipsoid structure was intact (arrow) and the boundary between the white and red pulp was clear; F: FCO high-dose group, the ellipsoid structure was intact (arrow) with no other lesions. All the pictures are ×400 magnification. FCO = flavonoids extracted from Chromolaena odorata Linn., LYM = lymphocytes

Figure 6: (a) Effect of FCO on thymus histopathology in mice (400×). A: blank control group; B: immunosuppressed group, the thymocytes of cortex decreased, in which the thymocytes were broken and the interlobular septum was widened (arrow); C: positive control group, the cortical thymocytes were dense and the thymic corpuscle was intact, whereas the interlobular septum was widened (arrow); D: FCO low-dose group, fewer thymocytes in cortex and thymocyte fragments (arrow); E: FCO medium-dose group, the thymocytes of cortex and the thymic corpuscle were normal (arrow); F: FCO high-dose group, the boundary between cortex and medulla was significant with intact thymic corpuscle structure and clear vein structure (arrow). All the pictures are ×400 magnification. (b) Effect of FCO on spleen histopathology in mice (400×). A: blank control group; B: immunosuppressed group, LYM decreased with disordered trabecular structure and hemorrhagic spots were found (arrow); C: positive control group, the trabecula were normal (arrow); D: FCO low-dose group, the LYM in white pulp had a decreased number (arrow); E: FCO medium-dose group, the ellipsoid structure was intact (arrow) and the boundary between the white and red pulp was clear; F: FCO high-dose group, the ellipsoid structure was intact (arrow) with no other lesions. All the pictures are ×400 magnification. FCO = flavonoids extracted from <i>Chromolaena odorata</i> Linn., LYM = lymphocytes