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  Indian J Med Microbiol
 

Figure 3: Effects of OPA on FCA-induced alterations in mRNA expression of NF-kβ, Ikβα, iNOs, and COX-2 (a). Quantitative representation of the mRNA expression of NF-kβ (b), Ikβα (c), iNOs (d), and COX-2 (e) in synovial tissues. Data are expressed as mean ± standard error of mean (n = 6) and analyzed by one-way ANOVA followed by Tukey's multiple range test. For comparison with AIA-control group: *P < 0.05, comparison with normal group: #P < 0.05 and comparison with one another: $p < 0.05. 1000 base pair (bp) ladder (lane 1), Normal group mRNA expression (lane 2); AIA control group mRNA expression (lane 3); Leflunomide group mRNA expression (lane 4) and OPA (10, 20, and 40 mg/kg) group mRNA expression (lane 5-7). AIA: Adjuvant-induced arthritis, LF: Leflunomide; OPA: Oxypaeoniflorin; NF-kβ: Nuclear factor kappa beta; Ikβα: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor-α; iNOs: inducible nitric oxide synthase; and COX-2: Cyclooxygenase-2

Figure 3: Effects of OPA on FCA-induced alterations in mRNA expression of NF-kβ, Ikβα, iNOs, and COX-2 (a). Quantitative representation of the mRNA expression of NF-kβ (b), Ikβα (c), iNOs (d), and COX-2 (e) in synovial tissues. Data are expressed as mean ± standard error of mean (<i>n</i> = 6) and analyzed by one-way ANOVA followed by Tukey's multiple range test. For comparison with AIA-control group: *<i>P</i> < 0.05, comparison with normal group: <sup>#</sup><i>P</i> < 0.05 and comparison with one another: <sup>$</sup><i>p</i> < 0.05. 1000 base pair (bp) ladder (lane 1), Normal group mRNA expression (lane 2); AIA control group mRNA expression (lane 3); Leflunomide group mRNA expression (lane 4) and OPA (10, 20, and 40 mg/kg) group mRNA expression (lane 5-7). AIA: Adjuvant-induced arthritis, LF: Leflunomide; OPA: Oxypaeoniflorin; NF-kβ: Nuclear factor kappa beta; Ikβα: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor-α; iNOs: inducible nitric oxide synthase; and COX-2: Cyclooxygenase-2