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  Indian J Med Microbiol
 

Figure 3: Effects of tanshinone IIA on phosphorylation of tau protein and inflammatory factors expression of SH-SY5Y cells injured by Aβ25–35. After treating with sodium 4-phenylbutyrate (5 mM) or indicated concentrations of tanshinone IIA on Aβ25–35-injured SH-SY5Y cells, (a) protein levels of phosphorylated tau proteins (Ser205, Ser396, and Ser413), and total tau protein (Tau-5) were measured by Western blot, (b) expression of inflammatory factors (TNF-α, IL-6, IL-1β, and IL-10) was measured by ELISA, and (c) mRNA expression levels of inflammatory factors (TNF-α, IL-6, IL-1β, and IL-10) were measured by qPCR. Statistical data are presented as mean ± standard deviation **P < 0.01, versus control group. #P < 0.05, ##P < 0.01, versus Aβ group. The experiments were independently repeated three times

Figure 3: Effects of tanshinone IIA on phosphorylation of tau protein and inflammatory factors expression of SH-SY5Y cells injured by Aβ<sub>25–35</sub>. After treating with sodium 4-phenylbutyrate (5 mM) or indicated concentrations of tanshinone IIA on Aβ<sub>25–35</sub>-injured SH-SY5Y cells, (a) protein levels of phosphorylated tau proteins (Ser205, Ser396, and Ser413), and total tau protein (Tau-5) were measured by Western blot, (b) expression of inflammatory factors (TNF-α, IL-6, IL-1β, and IL-10) was measured by ELISA, and (c) mRNA expression levels of inflammatory factors (TNF-α, IL-6, IL-1β, and IL-10) were measured by qPCR. Statistical data are presented as mean ± standard deviation **<i>P</i> < 0.01, versus control group. <sup>#</sup><i>P</i> < 0.05, <sup>##</sup><i>P</i> < 0.01, versus Aβ group. The experiments were independently repeated three times