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  Indian J Med Microbiol
 

Figure 7: Effect of deguelin on matrix metalloproteinase-2 expression by immunohistochemical analysis of colon tissues of dextran sulfate sodium-induced colitic mice. (a) Control animals displayed slight matrix metalloproteinase-2 expression (Group-I). A drastically elevated expression pattern of matrix metalloproteinase-2 was noted in the dextran sulfate sodium-provoked colitic mice (Group-II). Deguelin treated colitic mice revealed nearly very least matrix metalloproteinase-2 expression (Group-III). Sulfasalazine-treated mice also displayed the near-normal expression of matrix metalloproteinase-2 (Group-IV). (b) The graphical representation of matrix metalloproteinase-2 expression in the colon tissues of experimental animals. All values are depicted as mean ± standard deviation (n = 6). The level of statistical significance was calculated by one-way ANOVA followed by the DMRT test; note: *P < 0.05 when compared with the control group and **P < 0.05 when compared with dextran sulfate sodium-treated group

Figure 7: Effect of deguelin on matrix metalloproteinase-2 expression by immunohistochemical analysis of colon tissues of dextran sulfate sodium-induced colitic mice. (a) Control animals displayed slight matrix metalloproteinase-2 expression (Group-I). A drastically elevated expression pattern of matrix metalloproteinase-2 was noted in the dextran sulfate sodium-provoked colitic mice (Group-II). Deguelin treated colitic mice revealed nearly very least matrix metalloproteinase-2 expression (Group-III). Sulfasalazine-treated mice also displayed the near-normal expression of matrix metalloproteinase-2 (Group-IV). (b) The graphical representation of matrix metalloproteinase-2 expression in the colon tissues of experimental animals. All values are depicted as mean ± standard deviation (<i>n</i> = 6). The level of statistical significance was calculated by one-way ANOVA followed by the DMRT test; note: *<i>P</i> < 0.05 when compared with the control group and **<i>P</i> < 0.05 when compared with dextran sulfate sodium-treated group