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  Indian J Med Microbiol
 

Figure 2: The photomicrograph of thoracic aortas represents immunohistochemical staining with RAM-11 antibody from CN, HCD, ZPI, ZPII, and ZPIII groups. CN shows no IPC. HCD displays massive and diffuse IPCs within thick rising plaque (p) indicated by deep brownish-stained macrophages (black and yellow arrows). Aortas in ZPI, II and III groups demonstrate a significant reduction in plaque size (p) and the intensity of brownish color RAM-11 immunopositive foam cells compare to the thick plaque in HCD (black arrows). There is no reaction in the muscularis layer (m). Bar graph represents the quantification assay of IPC and INC cells. *indicates a statistical significance at P < 0.05 and #indicates a statistical significance at P < 0.01. L: Lumen; M: Media; A: Adventitia. Scale bars: 500 μm. CN: Control group; RAM-11: Regulation of ACE2 and morphogenesis 11; ZP: ZER-preventive; ZER: Zerumbone; IPC: Immunoreactive-positive cells; INC: Immunoreactive-negative cells

Figure 2: The photomicrograph of thoracic aortas represents immunohistochemical staining with RAM-11 antibody from CN, HCD, ZPI, ZPII, and ZPIII groups. CN shows no IPC. HCD displays massive and diffuse IPCs within thick rising plaque (p) indicated by deep brownish-stained macrophages (black and yellow arrows). Aortas in ZPI, II and III groups demonstrate a significant reduction in plaque size (p) and the intensity of brownish color RAM-11 immunopositive foam cells compare to the thick plaque in HCD (black arrows). There is no reaction in the muscularis layer (m). Bar graph represents the quantification assay of IPC and INC cells. *indicates a statistical significance at<i> P </i>< 0.05 and <sup>#</sup>indicates a statistical significance at<i> P </i>< 0.01. L: Lumen; M: Media; A: Adventitia. Scale bars: 500 μm. CN: Control group; RAM-11: Regulation of ACE2 and morphogenesis 11; ZP: ZER-preventive; ZER: Zerumbone; IPC: Immunoreactive-positive cells; INC: Immunoreactive-negative cells