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  Indian J Med Microbiol
 

Figure 2: Neuroprotective effect of alkaloid neferine on Parkinson's disease-induced mice motor coordination. The mice were subjected to Parkinson's disease induction with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (30 mg/kg bw) intraperitoneally for 5 consecutive days, nefereine (20 mg/kg bw) intraperitonial injection was given from day 10–14 of treatment period to Parkinson's disease-induced mice and nefereine (20 mg/kg bw) intraperitonial injection alone was administered for 14 days. Last 3 days of the treatment period, the mice were trained to rest on the rotating rod at 5 rpm rotation. 24 h after the last treatment period the mice were subjected to rota rod test at various speed 5 rpm (a), 10 rpm (b) and 15 rpm (c) for 5 min. The behavior pattern of the mice was video tapped and assessed for the average withstand time of each mice on the rotating rod. The data were statistically analyzed with Student's t-test using GraphPad Prism software and expressed as mean ± standard error of the mean. P < 0.05 was considered to statistically significant

Figure 2: Neuroprotective effect of alkaloid neferine on Parkinson's disease-induced mice motor coordination. The mice were subjected to Parkinson's disease induction with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (30 mg/kg bw) intraperitoneally for 5 consecutive days, nefereine (20 mg/kg bw) intraperitonial injection was given from day 10–14 of treatment period to Parkinson's disease-induced mice and nefereine (20 mg/kg bw) intraperitonial injection alone was administered for 14 days. Last 3 days of the treatment period, the mice were trained to rest on the rotating rod at 5 rpm rotation. 24 h after the last treatment period the mice were subjected to rota rod test at various speed 5 rpm (a), 10 rpm (b) and 15 rpm (c) for 5 min. The behavior pattern of the mice was video tapped and assessed for the average withstand time of each mice on the rotating rod. The data were statistically analyzed with Student's <i>t</i>-test using GraphPad Prism software and expressed as mean ± standard error of the mean. <i>P</i> < 0.05 was considered to statistically significant