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  Indian J Med Microbiol
 

Figure 5: Histology of CA1 region of hippocampus stained with H and E after 28 days of experimental protocol (×40). (a) SO group represents healthy neurons with prominent nuclei, (b) Aβ (1–42) infused group representing neuronal damage, eosinophilic stained cytoplasm, vacuolization and neuronal shrinkage, (c) MEVA (250 mg/kg) and (d) MEVA (500 mg/kg) treated groups representing mild neuronal injury with lesser number of eosiniphilic stained neurons, (e) Quantitative assessment of number of degenerated neurons in CA1 hippocampal section of rat brain. The values were expressed as mean ± SEM ###P < 0.001 versus SO, *P < 0.05 and **P < 0.01 versus Aβ (1–42) group. SO: Sham operated; Aβ: Amyloid beta; MEVA: Methanol extract of V. anthelmintica; CA1: Cornu ammonis 1; H and E: Hematoxylin and eosin

Figure 5: Histology of CA1 region of hippocampus stained with H and E after 28 days of experimental protocol (×40). (a) SO group represents healthy neurons with prominent nuclei, (b) Aβ (1–42) infused group representing neuronal damage, eosinophilic stained cytoplasm, vacuolization and neuronal shrinkage, (c) MEVA (250 mg/kg) and (d) MEVA (500 mg/kg) treated groups representing mild neuronal injury with lesser number of eosiniphilic stained neurons, (e) Quantitative assessment of number of degenerated neurons in CA1 hippocampal section of rat brain. The values were expressed as mean ± SEM <sup>###</sup><i>P</i> < 0.001 versus SO, *<i>P</i> < 0.05 and **<i>P</i> < 0.01 versus Aβ (1–42) group. SO: Sham operated; Aβ: Amyloid beta; MEVA: Methanol extract of <i>V. anthelmintica</i>; CA1: Cornu ammonis 1; H and E: Hematoxylin and eosin