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  Indian J Med Microbiol
 

Figure 8: Antiangiogenic activity of ZRPPP in vivo. (a) Peritoneal angiogenesis in normal, control, and treated mice. (b) Representative graph for MVD in normal, control, and treated animal peritoneum. (c) Histopathological analysis of MVD of peritoneal tissue. (d) Graphical representation of changes in MVD in the MVD H and E staining. (e) Reduction in angiogenesis in the CAM in ovo. (f) Representative graph of MVD in normal, control, and ZRPPP 25 μg in CAM. (g) Changes in VEGF levels in control and treated ascites. Statistical significance: * P < 0.05, **P < 0.001, ****P < 0.0001. ZRPPP: Zanthoxylum rhetsa partially purified proteins; CAM: Chorioallantoic membrane; MVD: Microvessel density; H and E staining: Hematoxylin and eosin staining; VEGF: Vascular endothelial growth factor

Figure 8: Antiangiogenic activity of <i>ZRPPP in vivo.</i> (a) Peritoneal angiogenesis in normal, control, and treated mice. (b) Representative graph for MVD in normal, control, and treated animal peritoneum. (c) Histopathological analysis of MVD of peritoneal tissue. (d) Graphical representation of changes in MVD in the MVD H and E staining. (e) Reduction in angiogenesis in the CAM <i>in ovo.</i> (f) Representative graph of MVD in normal, control, and <i>ZRPPP</i> 25 μg in CAM. (g) Changes in VEGF levels in control and treated ascites. Statistical significance: *<i> P </i>< 0.05, **<i>P</i> < 0.001, ****<i>P</i> < 0.0001. <i>ZRPPP</i>: <i>Zanthoxylum rhetsa</i> partially purified proteins; CAM: Chorioallantoic membrane; MVD: Microvessel density; H and E staining: Hematoxylin and eosin staining; VEGF: Vascular endothelial growth factor