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  Indian J Med Microbiol
 

Figure 5: Effects of muscarinic receptor antagonists and external and internal Ca2+ on BJIT-induced pacemaker potential depolarization of ICCs. (Aa) Methoctramine inhibited BJIT-induced responses. (Ab) 4-DAMP had no effect on BJIT-induced responses. (Da) In case of external Ca2+-free solution, BJIT induced the pacemaker potential depolarization. (Db) Thapsigargin prevented the BJIT-induced pacemaker potential depolarization. (B, C and E) Responses are summarized. **P < 0.01. CTRL: Control; BJIT: Bojungikki-tang; ICCs: Interstitial cells of Cajal; 4-DAMP: 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide

Figure 5: Effects of muscarinic receptor antagonists and external and internal Ca<sup>2+</sup> on BJIT-induced pacemaker potential depolarization of ICCs. (Aa) Methoctramine inhibited BJIT-induced responses. (Ab) 4-DAMP had no effect on BJIT-induced responses. (Da) In case of external Ca<sup>2+</sup>-free solution, BJIT induced the pacemaker potential depolarization. (Db) Thapsigargin prevented the BJIT-induced pacemaker potential depolarization. (B, C and E) Responses are summarized. **<i>P</i> < 0.01. CTRL: Control; BJIT: Bojungikki-tang; ICCs: Interstitial cells of Cajal; 4-DAMP: 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide