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  Indian J Med Microbiol
 

Figure 3: Effects of juglanin on FCA induced alterations in hepatic NF-κB (a), IκBα (b), ADAMTS-4 (c), and ADAMTS-5 (d) protein expressions in arthritic rats. Data are expressed as mean ± standard error mean (n = 4) and analyzed by one-way ANOVA followed by Tukey's multiple range test. #P < 0.05 as compared to normal group, *P < 0.05 as compared to the AIA-control group, and $P < 0.05 as compared to one another. Lane 1: Protein expression of normal rats; Lane 2: Protein expression of AIA control rats; Lane 3: Protein expression of Leflunomide (10 mg/kg, p. o.) treated rats; Lane 4: Protein expression of juglanin (10 mg/kg, p. o.) treated rats; Lane 5: Protein expression of juglanin (20 mg/kg, p. o.) treated rats and Lane 6: Protein expression of juglanin (40 mg/kg, p. o.) treated rats. AIA: Adjuvant-induced arthritis, LF: Leflunomide, J: Juglanin, NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, IκBα: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha, ADAMTS: A disintegrin and metalloproteinase with thrombospondin motifs

Figure 3: Effects of juglanin on FCA induced alterations in hepatic NF-κB (a), IκBα (b), ADAMTS-4 (c), and ADAMTS-5 (d) protein expressions in arthritic rats. Data are expressed as mean ± standard error mean (<i>n</i> = 4) and analyzed by one-way ANOVA followed by Tukey's multiple range test. <sup>#</sup><i>P</i> < 0.05 as compared to normal group, *<i>P</i> < 0.05 as compared to the AIA-control group, and <sup>$</sup><i>P</i> < 0.05 as compared to one another. Lane 1: Protein expression of normal rats; Lane 2: Protein expression of AIA control rats; Lane 3: Protein expression of Leflunomide (10 mg/kg, p. o.) treated rats; Lane 4: Protein expression of juglanin (10 mg/kg, p. o.) treated rats; Lane 5: Protein expression of juglanin (20 mg/kg, p. o.) treated rats and Lane 6: Protein expression of juglanin (40 mg/kg, p. o.) treated rats. AIA: Adjuvant-induced arthritis, LF: Leflunomide, J: Juglanin, NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, IκBα: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha, ADAMTS: A disintegrin and metalloproteinase with thrombospondin motifs