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  Indian J Med Microbiol
 

Figure 2: Cell death mechanism of MDA-MB-231 cells treated with IC50 concentrations of cCN and Dox for 24, 48, and 72 h. Data were expressed as a percentage relative to the vehicle control. PS: Annexin V binding activity of MDA-MB-231 cells, indicative of apoptosis (a). Loss of membrane integrity of MDA-MB-231 cells, indicative of secondary necrosis (b). Kinetic profiles of PS exposure (luminescence) and loss of plasma membrane integrity (fluorescence) of MDA-MB-231 cells (c) treated with IC50 concentrations of cCN (i), Dox (ii) and vehicle control (iii) for 24, 48, and 72 h. Data represent mean ± SD from three independent experiments (n = 3). *P ≤ 0.05 versus vehicle control

Figure 2: Cell death mechanism of MDA-MB-231 cells treated with IC<sub>50</sub> concentrations of cCN and Dox for 24, 48, and 72 h. Data were expressed as a percentage relative to the vehicle control. PS: Annexin V binding activity of MDA-MB-231 cells, indicative of apoptosis (a). Loss of membrane integrity of MDA-MB-231 cells, indicative of secondary necrosis (b). Kinetic profiles of PS exposure (luminescence) and loss of plasma membrane integrity (fluorescence) of MDA-MB-231 cells (c) treated with IC<sub>50</sub> concentrations of cCN (i), Dox (ii) and vehicle control (iii) for 24, 48, and 72 h. Data represent mean ± SD from three independent experiments (<i>n</i> = 3). *<i>P</i> ≤ 0.05 versus vehicle control