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  Indian J Med Microbiol
 

Figure 2: Effect of caffeic acid phenethyl ester on histopathological changes in acute (A) and subchronic (B) mice cardiotoxicity induced by cyclophosphamide alone or plus naproxen (H and E, ×400). Concomitant administration of caffeic acid phenethyl ester with cyclophosphamide and cyclophosphamide/naproxen attenuated their destructive effects and resulted in an improvement of the histological structures, which became comparable to that in the control group. Black arrow: red blood cells infiltration; yellow arrow: leukocytes infiltration; and green arrow: hypertrophy of cardiac fibers. Caffeic acid phenethyl ester alone had no effect on cardiac histopathology (data are not shown)

Figure 2: Effect of caffeic acid phenethyl ester on histopathological changes in acute (A) and subchronic (B) mice cardiotoxicity induced by cyclophosphamide alone or plus naproxen (H and E, ×400). Concomitant administration of caffeic acid phenethyl ester with cyclophosphamide and cyclophosphamide/naproxen attenuated their destructive effects and resulted in an improvement of the histological structures, which became comparable to that in the control group. Black arrow: red blood cells infiltration; yellow arrow: leukocytes infiltration; and green arrow: hypertrophy of cardiac fibers. Caffeic acid phenethyl ester alone had no effect on cardiac histopathology (data are not shown)