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  Indian J Med Microbiol
 

Figure 3:Morphological and cytological features of hepatocellular carcinoma cell line (HepG2) (a and b) treated with 1% dimethyl sulfoxide (vehicle control) (a), treated with compound 1 in a concentration of 100 μM (b) after 72 h of cell exposure to the investigated compound. (a) HepG2 grown as a control with dimethyl sulfoxide solvent, showing the characteristic monolayer of carcinoma cells, with the standard features of cellular atypia: nuclear and cytoplasmic pleomorphism, increased nucleus: cytoplasm ratio, highly irregularly-shaped cells (tadpole, caudate), irregular nuclear shapes, and hyperchromasia. (b) HepG2 with compound 1 addition shows a moderate decrease in the number of hepatocellular carcinoma cells and necrotic cells in suspension

Figure 3:Morphological and cytological features of hepatocellular carcinoma cell line (HepG2) (a and b) treated with 1% dimethyl sulfoxide (vehicle control) (a), treated with compound 1 in a concentration of 100 μM (b) after 72 h of cell exposure to the investigated compound. (a) HepG2 grown as a control with dimethyl sulfoxide solvent, showing the characteristic monolayer of carcinoma cells, with the standard features of cellular atypia: nuclear and cytoplasmic pleomorphism, increased nucleus: cytoplasm ratio, highly irregularly-shaped cells (tadpole, caudate), irregular nuclear shapes, and hyperchromasia. (b) HepG2 with compound 1 addition shows a moderate decrease in the number of hepatocellular carcinoma cells and necrotic cells in suspension