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  Indian J Med Microbiol
 

Figure 2:Morphological and cytological features of colorectal carcinoma cell line (HCT116) (a and b) treated with 1% dimethyl sulfoxide (vehicle control) (a), treated with compound 3 in a concentration of 100 μM (b) after 72 h of cell exposure to the investigated compound. (a) HCT116 grown as a control with dimethyl sulfoxide solvent, showing the characteristic monolayer of carcinoma cells, with the standard features of cellular atypia: nuclear and cytoplasmic pleomorphism, increased nucleus: cytoplasm ratio, highly irregularly-shaped cells (tadpole, caudate), irregular nuclear shapes, and hyperchromasia. (b) HCT116 with compound 3 addition shows a decreased number of colorectal carcinoma cells and necrotic cells in suspension

Figure 2:Morphological and cytological features of colorectal carcinoma cell line (HCT116) (a and b) treated with 1% dimethyl sulfoxide (vehicle control) (a), treated with compound 3 in a concentration of 100 μM (b) after 72 h of cell exposure to the investigated compound. (a) HCT116 grown as a control with dimethyl sulfoxide solvent, showing the characteristic monolayer of carcinoma cells, with the standard features of cellular atypia: nuclear and cytoplasmic pleomorphism, increased nucleus: cytoplasm ratio, highly irregularly-shaped cells (tadpole, caudate), irregular nuclear shapes, and hyperchromasia. (b) HCT116 with compound 3 addition shows a decreased number of colorectal carcinoma cells and necrotic cells in suspension