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  Indian J Med Microbiol
 

Figure 3: The effect of Clinacanthus nutans (a) 100% ethanolic, (b) 70% and (c) 50% aqueous ethanolic, and (d) 100% aqueous extracts on the release of histamine from IgE-mediated degranulated mast cells. Data were presented as mean ± standard error of the mean of three independent experiments in triplicate. Ethanolic extracts did not inhibit histamine even at 1000 μg/ml while significant inhibitions were recorded by aqueous extract at 5mg/ml onward. Ketotifen fumarate (K), a clinically used mast cell stabilizer at 300 μM showed significant inhibition in all experiments. ***P ≤ 0.001 significantly different from dinitrophenyl-bovine serum albumin -challenged control

Figure 3: The effect of <i>Clinacanthus nutans</i> (a) 100% ethanolic, (b) 70% and (c) 50% aqueous ethanolic, and (d) 100% aqueous extracts on the release of histamine from IgE-mediated degranulated mast cells. Data were presented as mean ± standard error of the mean of three independent experiments in triplicate. Ethanolic extracts did not inhibit histamine even at 1000 μg/ml while significant inhibitions were recorded by aqueous extract at 5mg/ml onward. Ketotifen fumarate (K), a clinically used mast cell stabilizer at 300 μM showed significant inhibition in all experiments. ***<i>P</i> ≤ 0.001 significantly different from dinitrophenyl-bovine serum albumin -challenged control