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  Indian J Med Microbiol
 

Figure 3: Cordyceps militaris fraction inhibits vascular endothelial growth factor-induced microvessel sprouting ex vivo. (a) Aortic rings were photographed (4×). Arrows pointed to microvascular sprouting of rat aortic rings. (b) Numbers of sprouts were assessed semi-quantitatively by Image-Pro plus Version (IOD integrated optical density). The aortas isolated from standard deviation rats were placed in the Matrigel-coated plates, overlayed with Matrigel, and then treated with vascular endothelial growth factor (10 ng/mL) in the presence of 0, 0.625, 1.25, 2.5, or 5 μg/mL of Cordyceps militaris fraction for 7 days. At the end of incubation, the sprouting microvessels were fixed. **P < 0.01 versus vascular endothelial growth factor-treated group

Figure 3: <i>Cordyceps militaris</i> fraction inhibits vascular endothelial growth factor-induced microvessel sprouting <i>ex vivo</i>. (a) Aortic rings were photographed (4×). Arrows pointed to microvascular sprouting of rat aortic rings. (b) Numbers of sprouts were assessed semi-quantitatively by Image-Pro plus Version (IOD integrated optical density). The aortas isolated from standard deviation rats were placed in the Matrigel-coated plates, overlayed with Matrigel, and then treated with vascular endothelial growth factor (10 ng/mL) in the presence of 0, 0.625, 1.25, 2.5, or 5 μg/mL of <i>Cordyceps militaris</i> fraction for 7 days. At the end of incubation, the sprouting microvessels were fixed. **<i>P</i> < 0.01 versus vascular endothelial growth factor-treated group