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  Indian J Med Microbiol
 

Figure 5: Photomicrograph of immunohistochemical staining revealing nuclear factor kappa-B activation in liver cells. (a) Mice treated with normal chow diet showing normal liver cells. (b) Mice treated with high fat diet for a period of 8 weeks. (c) Treatment of embelin (50 mg/kg/day, p.o.) from 5th to 8th week in high fat diet fed mice. (d) Treatment of orlistat (10 mg/kg/day, p.o.) from 5th to 8th week in high fat diet fed mice. Black arrows are showing nuclear factor kappa-B activation. Data are expressed as mean ± standard error of mean (n = 6 animals/group). Significance difference was determined by one-way analysis of variance followed by Tukey's multiple comparisons test. ***P < 0.001 high fat diet versus normal control;###P < 0.001 embelin 50 mg versus high fat diet;†††P < 0.001 orlistat 10 mg versus high fat diet

Figure 5: Photomicrograph<b></b>  of immunohistochemical staining revealing nuclear factor kappa-B activation in liver cells. (a) Mice treated with normal chow diet showing normal liver cells. (b) Mice treated with high fat diet for a period of 8 weeks. (c) Treatment of embelin (50 mg/kg/day, p.o.) from 5<sup>th</sup> to 8<sup>th</sup> week in high fat diet fed mice. (d) Treatment of orlistat (10 mg/kg/day, p.o.) from 5<sup>th</sup> to 8<sup>th</sup> week in high fat diet fed mice. Black arrows are showing nuclear factor kappa-B activation. Data are expressed as mean ± standard error of mean (<i>n</i> = 6 animals/group). Significance difference was determined by one-way analysis of variance followed by Tukey's multiple comparisons test. ***<i>P</i> < 0.001 high fat diet versus normal control;<sup>###</sup><i>P</i> < 0.001 embelin 50 mg versus high fat diet;<sup>†††</sup><i>P</i> < 0.001 orlistat 10 mg versus high fat diet