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  Indian J Med Microbiol
 

Figure 6: Effect of herniarin on protein expressions of PI3K, Akt, and HMGCoAR in mammary tissues of all experimental animals. Where (a) relative protein expression for PI3K, (b) relative protein expression for Akt. Where each value shows mean ± standard error of mean (n = 6); where Groups II, III, and IV compared with Group I. (c) relative protein expression for HMGCoAR where each value shows mean ± standard error of mean (n = 6); where, a – Groups II, III, and IV compared with Group I; b – Groups III and IV compared to Group II; ***P < 0.001; **P < 0.01; *P < 0.05;nsP > 0.05; Group I – Control; Group II – Induced control (DMBA, 20 mg), Group III – DMBA (20 mg) + herniarin (20 mg/kg, b. w.); Group IV – DMBA (20 mg) + herniarin (40 mg/kg, b. w.). DMBA: 7,12-dimethylbenz(a)anthracene; PI3K: phosphoinositide 3-kinase; HMGCoAR: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Figure 6: Effect of herniarin on protein expressions of PI3K, Akt, and HMGCoAR in mammary tissues of all experimental animals. Where (a) relative protein expression for PI3K, (b) relative protein expression for Akt. Where each value shows mean ± standard error of mean (<i>n</i> = 6); where Groups II, III, and IV compared with Group I. (c) relative protein expression for HMGCoAR where each value shows mean ± standard error of mean (<i>n</i> = 6); where, a – Groups II, III, and IV compared with Group I; b – Groups III and IV compared to Group II; ***<i>P</i> < 0.001; **<i>P</i> < 0.01; *<i>P</i> < 0.05;<sup>ns</sup><i>P</i> > 0.05; Group I – Control; Group II – Induced control (DMBA, 20 mg), Group III – DMBA (20 mg) + herniarin (20 mg/kg, b. w.); Group IV – DMBA (20 mg) + herniarin (40 mg/kg, b. w.). DMBA: 7,12-dimethylbenz(a)anthracene; PI3K: phosphoinositide 3-kinase; HMGCoAR: 3-hydroxy-3-methylglutaryl-coenzyme A reductase