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  Indian J Med Microbiol
 

Figure 2: (a) In vitro 3-hydroxy-3-methylglutaryl-coenzyme A reductase ( inhibitory activity of herniarin (IC50: 103.1 nM) (n = 3), (b) Effect of herniarin on body weight (g) of cancer-induced rats where each value shows mean ± standard error of mean (n = 6); comparisons: a – Groups II, III, and IV compared with Group I; b – Groups III and IV compared to Group II, (c) effect of herniarin on tumor weight of cancer bearing rats where each value shows mean ± standard error of mean (n = 6); comparisons: groups III and V compared with Group II; ***P < 0.001; **P < 0.01; *P < 0.05;nsP > 0.05; Group I – Control; Group II – Induced control (DMBA, 20 mg); Group III – DMBA (20 mg) + herniarin (20 mg/kg, b. w.); Group IV – DMBA (20 mg) + herniarin (40 mg/kg b. w.). DMBA: 7,12-dimethylbenz(a)anthracene

Figure 2: (a)<i> In vitro </i> 3-hydroxy-3-methylglutaryl-coenzyme A reductase ( inhibitory activity of herniarin (IC<sub>50: </sub>103.1 nM) (<i>n</i> = 3), (b) Effect of herniarin on body weight (g) of cancer-induced rats where each value shows mean ± standard error of mean (<i>n</i> = 6); comparisons: a – Groups II, III, and IV compared with Group I; b – Groups III and IV compared to Group II, (c) effect of herniarin on tumor weight of cancer bearing rats where each value shows mean ± standard error of mean <i>(n</i> = 6); comparisons: groups III and V compared with Group II; ***<i>P</i> < 0.001; **<i>P</i> < 0.01; *<i>P</i> < 0.05;<sup>ns</sup><i>P</i> > 0.05; Group I – Control; Group II – Induced control (DMBA, 20 mg); Group III – DMBA (20 mg) + herniarin (20 mg/kg, b. w.); Group IV – DMBA (20 mg) + herniarin (40 mg/kg b. w.). DMBA: 7,12-dimethylbenz(a)anthracene