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  Indian J Med Microbiol
 

Figure 3: Hot-plate escape latencies after intracerebroventricular administration of low-molecular-weight compound, morphine or saline in mice. (a) Time course of the increase in latencies in the tail-flick test induced by intracerebroventricular injection of low-molecular-weight compound (100 and 50 μg), morphine (20 μg/animal) or saline (NaCl - 150 mM). The Antinociception index were analyzed by two-way analysis of variance, followed by the Bonferroni post hoc test. *Significant differences compared to saline P < 0.05. §Significant differences compared to 50-μg dose; +Significant differences compared to 100-μg dose. **P < 0,01, ***P < 0,001. §§(P < 0,01), §§§(P < 0,001), ++(P < 0,01), +++(P < 0,001)

Figure 3: Hot-plate escape latencies after intracerebroventricular administration of low-molecular-weight compound, morphine or saline in mice. (a) Time course of the increase in latencies in the tail-flick test induced by intracerebroventricular injection of low-molecular-weight compound (100 and 50 μg), morphine (20 μg/animal) or saline (NaCl - 150 mM). The Antinociception index were analyzed by two-way analysis of variance, followed by the Bonferroni <i>post hoc</i> test. *Significant differences compared to saline <i>P</i> < 0.05. <sup>§</sup>Significant differences compared to 50-μg dose; <sup>+</sup>Significant differences compared to 100-μg dose. **<i>P</i> < 0,01, ***<i>P</i> < 0,001. <sup>§§</sup>(<i>P</i> < 0,01), <sup>§§§</sup>(<i>P</i> < 0,001), <sup>++</sup>(<i>P</i> < 0,01), <sup>+++</sup>(<i>P</i> < 0,001)