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  Indian J Med Microbiol
 

Figure 1: Tail-flick times after intracerebroventricular injections of low-molecular-weight compound, morphine or saline in mice. (a) Time course of the increase in latencies in the tail-flick test induced by intracerebroventricular injection of low-molecular-weight compound (100, 50, and 25 μg), morphine (20 μg/animal), or saline (NaCl -150 mM). Antinociception index were analyzed by two-way analysis of variance, followed by the Bonferroni post hoc test. *Significant differences compared to saline. #Significant differences compared to morphine; §Significant differences compared to 100-μg dose. *P < 0.05, **P < 0,01, ***P < 0,001

Figure 1: Tail-flick times after intracerebroventricular injections of low-molecular-weight compound, morphine or saline in mice. (a) Time course of the increase in latencies in the tail-flick test induced by intracerebroventricular injection of low-molecular-weight compound (100, 50, and 25 μg), morphine (20 μg/animal), or saline (NaCl -150 mM). Antinociception index were analyzed by two-way analysis of variance, followed by the Bonferroni post hoc test. *Significant differences compared to saline. <sup>#</sup>Significant differences compared to morphine; <sup>§</sup>Significant differences compared to 100-μg dose. *<i>P</i> < 0.05, **<i>P</i> < 0,01, ***<i>P</i> < 0,001