Close
  Indian J Med Microbiol
 

Figure 6: Inhibitory effects of Geranium koreanum on inflammatory protein and cytokine expression in esophagus of acute reflux esophagitis-induced rats. Expression of (a) cytokines tumor necrosis factor-alfa and interleukin-1 β; (b) inflammatory protein inducible nitric oxide synthase and cyclooxygenase-2; (c) p-extracellular-signal-regulated kinase, p-IκB-α, and p-p65 proteins. Rats were pretreated with 100 and 200 mg/kg body weight Geranium koreanum excluding normal and reflux esophagitis control rats for 90 min before surgery, under inhalation anesthesia. Then, 5 h later, the esophagus was cut, and the abdomen was opened and dissected from each rat. Data are means ± standard deviation. Significance: ###P < 0.001, ##P < 0.01 and #P < 0.05 compared with normal control; **P < 0.01 and *P < 0.05 compared with reflux esophagitis control

Figure 6: Inhibitory effects of <i>Geranium koreanum</i> on inflammatory protein and cytokine expression in esophagus of acute reflux esophagitis-induced rats. Expression of (a) cytokines tumor necrosis factor-alfa and interleukin-1 β; (b) inflammatory protein inducible nitric oxide synthase and cyclooxygenase-2; (c) p-extracellular-signal-regulated kinase, p-IκB-α, and p-p65 proteins. Rats were pretreated with 100 and 200 mg/kg body weight <i>Geranium koreanum</i> excluding normal and reflux esophagitis control rats for 90 min before surgery, under inhalation anesthesia. Then, 5 h later, the esophagus was cut, and the abdomen was opened and dissected from each rat. Data are means ± standard deviation. Significance: <sup>###</sup><i>P</i> < 0.001, <sup>##</sup><i>P</i> < 0.01 and <sup>#</sup><i>P</i> < 0.05 compared with normal control; **<i>P</i> < 0.01 and *<i>P</i> < 0.05 compared with reflux esophagitis control