Close
  Indian J Med Microbiol
 

Figure 2: (a) Changes in concentrations of serum T3 (ng/ml × 10−1), T4 (ng/ml × 10) and thyrotropin (μIU/ml) levels and in hepatic 5'DI (ng/ml/h) activity, following the administration of ethyl acetate Piper betle (50 mg/kg/d) to the L-T4-induced animals. Each vertical bar represents the mean ± standard error of the mean. (n = 7). aP < 0.001, bP < 0.01, and cP < 0.01 as compared to the respective control value, whereas ***P < 0.001 and **P < 0.01 as compared to the respective value of thyroxine-treated animals. One-way ANOVA, followed by Tukey's posttest. Ethyl acetate Piper betle-induced amelioration in thyroid indices in hyperthyroid rats is clearly observed. (b) Changes in hepatic G-6-Pase (μM of Pi liberated/h/mg protein) and Na+-K+-ATPase activity (μM of Pi liberated/h/mg of protein) following the administration of ethyl acetate Piper betle (50 mg/kg/d) to the L-T4-induced animals. Each vertical bar represents the mean ± standard error of the mean (n = 7); aP < 0.001 and bP < 0.01 as compared to the respective control value, whereas ***P < 0.001 and **P < 0.01 as compared to the respective value of thyroxine-treated animals. One-way ANOVA, followed by Tukey's post-test. Ethyl acetate Piper betle reverses the changes induced by T4

Figure 2: (a) Changes in concentrations of serum T<sub>3</sub> (ng/ml × 10<sup>−1</sup>), T<sub>4</sub> (ng/ml × 10) and thyrotropin (μIU/ml) levels and in hepatic 5'DI (ng/ml/h) activity, following the administration of ethyl acetate <i>Piper betle</i> (50 mg/kg/d) to the L-T<sub>4</sub>-induced animals. Each vertical bar represents the mean ± standard error of the mean. (<i>n</i> = 7). <sup>a</sup><i>P</i> < 0.001, <sup>b</sup><i>P</i> < 0.01, and <sup>c</sup><i>P</i> < 0.01 as compared to the respective control value, whereas ***<i>P</i> < 0.001 and **<i>P</i> < 0.01 as compared to the respective value of thyroxine-treated animals. One-way ANOVA, followed by Tukey's posttest. Ethyl acetate <i>Piper betle</i>-induced amelioration in thyroid indices in hyperthyroid rats is clearly observed. (b) Changes in hepatic G-6-Pase (μM of Pi liberated/h/mg protein) and Na<sup>+</sup>-K<sup>+</sup>-ATPase activity (μM of Pi liberated/h/mg of protein) following the administration of ethyl acetate <i>Piper betle</i> (50 mg/kg/d) to the L-T<sub>4</sub>-induced animals. Each vertical bar represents the mean ± standard error of the mean (<i>n</i> = 7); <sup>a</sup><i>P</i> < 0.001 and <sup>b</sup><i>P</i> < 0.01 as compared to the respective control value, whereas ***<i>P</i> < 0.001 and **<i>P</i> < 0.01 as compared to the respective value of thyroxine-treated animals. One-way ANOVA, followed by Tukey's post-test. Ethyl acetate <i>Piper betle</i> reverses the changes induced by T<sub>4</sub>