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  Indian J Med Microbiol
 

Figure 3: Effect of Osthole on the expression of key proteins in Wnt/β-catenin signaling pathway and endoplasmic reticular stress at 2d. (a) Western blot assay of key proteins in Wnt/β-catenin signaling pathway and endoplasmic reticular stress. (b-f) Quantification of CHOP, GRP78, PDI, Wnt1, and β-catenin protein densitometry. The expression of CHOP, GRP78, PDI, Wnt1, and β-catenin protein was upregulated by Osthole at 2d (10−4 M). The expression of Wnt1 was also upregulated by Osthole at 2d (10−5 M). Data shown were expressed as mean ± standard deviation (n = 3, one-way ANOVA and LSD-t test). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

Figure 3: Effect of Osthole on the expression of key proteins in Wnt/β-catenin signaling pathway and endoplasmic reticular stress at 2d. (a) Western blot assay of key proteins in Wnt/β-catenin signaling pathway and endoplasmic reticular stress. (b-f) Quantification of CHOP, GRP78, PDI, Wnt1, and β-catenin protein densitometry. The expression of CHOP, GRP78, PDI, Wnt1, and β-catenin protein was upregulated by Osthole at 2d (10<sup>−4</sup> M). The expression of Wnt1 was also upregulated by Osthole at 2d (10<sup>−5</sup> M). Data shown were expressed as mean ± standard deviation (<i>n</i> = 3, one-way ANOVA and LSD-t test). *<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001, ****<i>P</i> < 0.0001