Figure 4: Effect of berberine on forced swim test (a), tail suspension test (b), total distance traveled (c), center square entries, and time duration of center square (d) in open field test of chronic social defeat stress mice. n = 8 per group; ^#P < 0.05, ^##P < 0.01 versus control, *P < 0.05, **P < 0.01 versus chronic social defeat stress by analysis of variance followed by Bonferroni's post hoc test. Data are expressed as means ± standard error of the mean