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  Indian J Med Microbiol
 

Figure 5: (a) Acute aldicarb resistance in 5,7-dihydroxy-4-methoxyflavone supplemented wild type worms. The age synchronized 5,7-dihydroxy-4-methoxyflavone treated or untreated wildtype worms were exposed to aldicarb (1 mM) for 6 h. 5,7-dihydroxy-4-methoxyflavone treatments (5, 25 and 50 μM) delay the effect of aldicarb on wildtype worms. Thus, 5,7-dihydroxy-4-methoxyflavone provides resistance to the worms in the presence of aldicarb treatment as compared with control. Differences between the data were considered significant at P ≤ 0.05. Error Bars represent means ± standard error of the mean. *P ≤ 0.05, **P ≤ 0.0001. (b) Acute aldicarb resistance in 5,7-dihydroxy-4-methoxyflavone supplemented CL2006 worms. The age synchronized 5,7-dihydroxy-4-methoxyflavone treated or untreated CL2006 worms were exposed to aldicarb (1 mM) for 6 h. 5,7-dihydroxy-4-methoxyflavone treatments (5, 25 and 50 μM) delay the effect of aldicarb on CL2006 worms. Thus, 5,7-dihydroxy-4-methoxyflavone provides resistance to the worms in the presence of aldicarb treatment as compared with control. Differences between the data were considered significant at P ≤ 0.05. Error bars represent means ± standard error of the mean. *P ≤ 0.05, **P ≤ 0.0001. (c) In chronic aldicarb assay, the age synchronized N2 wildtype worms were exposed to different concentrations of 5,7-dihydroxy-4-methoxyflavone (5, 25 and 50 μM) in the presence of aldicarb treatment (0.1 mM). 5,7-dihydroxy-4-methoxyflavone treatments exhibited significant increase in the lifespan of N2 worms in comparison to control in the presence of aldicarb. The lifespan data were processed using the Kaplan–Meir survival analysis in Medcalc 12.7.7.0 software. (d) The age synchronized CL2006 worms were exposed to different concentrations of 5,7-dihydroxy-4-methoxyflavone (5, 25 and 50 μM) in the presence of aldicarb treatment (0.1 mM). 5,7-dihydroxy-4-methoxyflavone treatments exhibited significant increase in the lifespan of CL2006 worms in comparison to control in the presence of aldicarb. The lifespan data were processed using the Kaplan–Meir survival analysis in Medcalc 12.7.7.0 software

Figure 5: (a) Acute aldicarb resistance in 5,7-dihydroxy-4-methoxyflavone supplemented wild type worms. The age synchronized 5,7-dihydroxy-4-methoxyflavone treated or untreated wildtype worms were exposed to aldicarb (1 mM) for 6 h. 5,7-dihydroxy-4-methoxyflavone treatments (5, 25 and 50 μM) delay the effect of aldicarb on wildtype worms. Thus, 5,7-dihydroxy-4-methoxyflavone provides resistance to the worms in the presence of aldicarb treatment as compared with control. Differences between the data were considered significant at <i>P</i> ≤ 0.05. Error Bars represent means ± standard error of the mean. *<i>P</i> ≤ 0.05, **<i>P</i> ≤ 0.0001. (b) Acute aldicarb resistance in 5,7-dihydroxy-4-methoxyflavone supplemented CL2006 worms. The age synchronized 5,7-dihydroxy-4-methoxyflavone treated or untreated CL2006 worms were exposed to aldicarb (1 mM) for 6 h. 5,7-dihydroxy-4-methoxyflavone treatments (5, 25 and 50 μM) delay the effect of aldicarb on CL2006 worms. Thus, 5,7-dihydroxy-4-methoxyflavone provides resistance to the worms in the presence of aldicarb treatment as compared with control. Differences between the data were considered significant at <i>P</i> ≤ 0.05. Error bars represent means ± standard error of the mean. *<i>P</i> ≤ 0.05, **<i>P</i> ≤ 0.0001. (c) In chronic aldicarb assay, the age synchronized N2 wildtype worms were exposed to different concentrations of 5,7-dihydroxy-4-methoxyflavone (5, 25 and 50 μM) in the presence of aldicarb treatment (0.1 mM). 5,7-dihydroxy-4-methoxyflavone treatments exhibited significant increase in the lifespan of N2 worms in comparison to control in the presence of aldicarb. The lifespan data were processed using the Kaplan–Meir survival analysis in Medcalc 12.7.7.0 software. (d) The age synchronized CL2006 worms were exposed to different concentrations of 5,7-dihydroxy-4-methoxyflavone (5, 25 and 50 μM) in the presence of aldicarb treatment (0.1 mM). 5,7-dihydroxy-4-methoxyflavone treatments exhibited significant increase in the lifespan of CL2006 worms in comparison to control in the presence of aldicarb. The lifespan data were processed using the Kaplan–Meir survival analysis in Medcalc 12.7.7.0 software