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  Indian J Med Microbiol
 

Figure 3: Effect of simvastatin (Sim) on lipopolysaccharide-induced tumor necrosis factor-α generation in BV-2 microglial cells (a) or primary microglial cells. (b) Microglial cells pretreated with simvastatin for 30 min, and then, lipopolysaccharide was added and cultured for 24 hours. tumor necrosis factor-α generation in culture media was determined using enzyme-linked immunosorbent assay kit. Data represent mean ± standard deviation of at least three independent experiments. Lipopolysaccharide-treated cells compared to simvastatin-treated cells. Symbol mark indicates significant differences from lipopolysaccharide alone treatment group (*P < 0.05)

Figure 3: Effect of simvastatin (Sim) on lipopolysaccharide-induced tumor necrosis factor-α generation in BV-2 microglial cells (a) or primary microglial cells. (b) Microglial cells pretreated with simvastatin for 30 min, and then, lipopolysaccharide was added and cultured for 24 hours. tumor necrosis factor-α generation in culture media was determined using enzyme-linked immunosorbent assay kit. Data represent mean ± standard deviation of at least three independent experiments. Lipopolysaccharide-treated cells compared to simvastatin-treated cells. Symbol mark indicates significant differences from lipopolysaccharide alone treatment group (*<i>P</i> < 0.05)