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  Indian J Med Microbiol
 

Figure 4: NFκB-positive cells. (a) Immunohistochemistry (×400). Bar, 60 μm. NFκB immunostaining was rare in control groups (both non-OVX and OVX groups), whereas NFκB-positive cells increased in number in NASH groups. Number of NFκB-positive cells was decreased in NASH with 16 mg/kg body weight genistein. (b) Percentage of NFκB-positive cells was determined using Image Scope®. In non-OVX rats, diet-induced NASH increased the percentage of NFκB-positive cells (P < 0.001) which significantly reduced after administration of genistein (P < 0.001). In OVX rats, diet also increased the percentage of NFκB-positive cells (P < 0.05); however, genistein could not decrease NFκB-positive cells. *P < 0.05 compared with control group; **P < 0.01 compared with control group; ##P < 0.01 compared with diet-induced NASH group. NFκB: Nuclear factor kappa B; NASH: Nonalcoholic steatohepatitis; OVX: Ovariectomized

Figure 4: NFκB-positive cells. (a) Immunohistochemistry (×400). Bar, 60 μm. NFκB immunostaining was rare in control groups (both non-OVX and OVX groups), whereas NFκB-positive cells increased in number in NASH groups. Number of NFκB-positive cells was decreased in NASH with 16 mg/kg body weight genistein. (b) Percentage of NFκB-positive cells was determined using Image Scope<sup>®</sup>. In non-OVX rats, diet-induced NASH increased the percentage of NFκB-positive cells (<i>P</i> < 0.001) which significantly reduced after administration of genistein (<i>P</i> < 0.001). In OVX rats, diet also increased the percentage of NFκB-positive cells (<i>P</i> < 0.05); however, genistein could not decrease NFκB-positive cells. *<i>P</i> < 0.05 compared with control group; **<i>P</i> < 0.01 compared with control group; <sup>##</sup><i>P</i> < 0.01 compared with diet-induced NASH group. NFκB: Nuclear factor kappa B; NASH: Nonalcoholic steatohepatitis; OVX: Ovariectomized