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  Indian J Med Microbiol
 

Figure 1: H and E staining and histological feature score following Brunt's criteria. (a) H and E (×100). (b) Steatosis scores between groups. HFHF diet-induced NASH significantly increased in both non-OVX and OVX rats (P < 0.01 compared with control group). Genistein significantly reduced steatosis scores in OVX rats (P < 0.01 compared with NASH group). (c) Lobular inflammation score. Genistein decreased lobular inflammatory score only in OVX rats (P < 0.01). (d) Hepatocellular ballooning score. *P < 0.05 compared with control group, **P < 0.01 compared with control group, ##P <0.01 compared with diet-induced NASH group. HFHF: High-fat high-fructose; OVX: Ovariectomized; NASH: Nonalcoholic steatohepatitis

Figure 1: H and E staining and histological feature score following Brunt's criteria. (a) H and E (×100). (b) Steatosis scores between groups. HFHF diet-induced NASH significantly increased in both non-OVX and OVX rats (<i>P</i> < 0.01 compared with control group). Genistein significantly reduced steatosis scores in OVX rats (<i>P</i> < 0.01 compared with NASH group). (c) Lobular inflammation score. Genistein decreased lobular inflammatory score only in OVX rats (<i>P</i> < 0.01). (d) Hepatocellular ballooning score. *<i>P</i> < 0.05 compared with control group, **<i>P</i> < 0.01 compared with control group, <sup>##</sup><i>P</i> <0.01 compared with diet-induced NASH group. HFHF: High-fat high-fructose; OVX: Ovariectomized; NASH: Nonalcoholic steatohepatitis