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  Indian J Med Microbiol
 

Figure 1: Combination effect of tumor necrosis factor-related apoptosis-inducing ligand and Coptidis Rhizoma or Curcumae longae Rhizoma in A549 cells. (a) Dose-dependent effect of tumor necrosis factor-related apoptosis-inducing ligand in A549 and H460 cells. A549 cells showed resistance to tumor necrosis factor-related apoptosis-inducing ligand. (b and c) Synergistic effect of tumor necrosis factor-related apoptosis-inducing ligand and CR or CLR, respectively, in A549 cells. A549 cells were incubated with tumor necrosis factor-related apoptosis-inducing ligand (40 ng/ml) and various concentrations of Coptidis Rhizoma or Curcumae longae Rhizoma (0, 100, 200, and 400 μg/ml) for 48 h, and cytotoxicity was measured using MTT assay. (d and e) Combination index of tumor necrosis factor-related apoptosis-inducing ligand and Coptidis Rhizoma or Curcumae longae Rhizoma, respectively. Combination index <1 indicates synergistic effects of drug combinations

Figure 1: Combination effect of tumor necrosis factor-related apoptosis-inducing ligand and <i>Coptidis Rhizoma</i> or <i>Curcumae longae Rhizoma</i> in A549 cells. (a) Dose-dependent effect of tumor necrosis factor-related apoptosis-inducing ligand in A549 and H460 cells. A549 cells showed resistance to tumor necrosis factor-related apoptosis-inducing ligand. (b and c) Synergistic effect of tumor necrosis factor-related apoptosis-inducing ligand and CR or CLR, respectively, in A549 cells. A549 cells were incubated with tumor necrosis factor-related apoptosis-inducing ligand (40 ng/ml) and various concentrations of <i>Coptidis Rhizoma</i> or <i>Curcumae longae Rhizoma</i> (0, 100, 200, and 400 μg/ml) for 48 h, and cytotoxicity was measured using MTT assay. (d and e) Combination index of tumor necrosis factor-related apoptosis-inducing ligand and <i>Coptidis Rhizoma</i> or <i>Curcumae longae Rhizoma</i>, respectively. Combination index <1 indicates synergistic effects of drug combinations