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  Indian J Med Microbiol
 

Figure 3: Expression of p-CREB, Nurr1 and BDNF in the hippocampus of rats detected by immunohistochemistry. p-CREB (A1-A4), Nurr1 (B1-B4) and BDNF (C1-C4) were detected using immunohistochemistry. Photomicrographs are representative of results from multiple brain sections obtained from four animals in each treatment group. Quantitative analysis is shown in (D-F). Scale bar: 50 μm. Data are expressed as mean values ± standard error of mean. **P < 0.01 versus the control group; ##P < 0.01 versus the ketamine conditioned place preference group via Bonferroni post hoc analysis after one-way analysis of variance. p-CREB: Phosphorylated cAMP response element binding protein, Nurr1: Nuclear receptor-related-1, BDNF: Brain-derived neurotrophic factor

Figure 3: Expression of p-CREB, Nurr1 and BDNF in the hippocampus of rats detected by immunohistochemistry. p-CREB (A1-A4), Nurr1 (B1-B4) and BDNF (C1-C4) were detected using immunohistochemistry. Photomicrographs are representative of results from multiple brain sections obtained from four animals in each treatment group. Quantitative analysis is shown in (D-F). Scale bar: 50 μm. Data are expressed as mean values ± standard error of mean. **<i>P</i> < 0.01 versus the control group; <sup>##</sup><i>P</i> < 0.01 versus the ketamine conditioned place preference group via Bonferroni <i>post hoc</i> analysis after one-way analysis of variance. p-CREB: Phosphorylated cAMP response element binding protein, Nurr1: Nuclear receptor-related-1, BDNF: Brain-derived neurotrophic factor