Close
  Indian J Med Microbiol
 

Figure 5: In vitro stability studies of 5-O-methyvisammiol (MVL) in rat hepatic system and plasma.One hundred microliters of simulated intestinal fluid (SIF) containing MVL or cimifuginwas first coincubated with 30% in vitro liver tissue homogenate or plasma sample of rats at 37°C in a shaking water bath.Fifteenminutes later, metabolic stability of these two chemicals was evaluated and compared by HPLCanalysis of parent drugs left usingrelative peak area, which was obtained by designating the actual peak area at 0 min as a value of 100%

Figure 5: <i>In vitro</i> stability studies of 5-O-methyvisammiol (MVL) in rat hepatic system and plasma.One hundred microliters of simulated intestinal fluid (SIF) containing MVL or cimifuginwas first coincubated with 30% <i>in vitro</i> liver tissue homogenate or plasma sample of rats at 37°C in a shaking water bath.Fifteenminutes later, metabolic stability of these two chemicals was evaluated and compared by HPLCanalysis of parent drugs left usingrelative peak area, which was obtained by designating the actual peak area at 0 min as a value of 100%