Figure 3: Photomicrographs of Masson's trichrome-stained liver sections of (a) control rats showing normal little collagen fibers specially in the portal area, (b) carbon tetrachloride-intoxicated rats showing large patches of fibrous tissue, (c) carbon tetrachloride-intoxicated rats treated with silymarin alone, (d) silymarin and chlorogenic acid, (e) silymarin and melatonin showing small patches of collagen deposition and (f ) carbon tetrachloride-intoxicated rats treated with silymarin, chlorogenic acid, and melatonin showing apparently normal collagen distribution within liver tissue