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  Indian J Med Microbiol
 

Figure 2: Photomicrographs of H and E-stained liver sections of (a) control rats, (b) carbon tetrachloride-intoxicated rats showing focal areas with massive degeneration, necrosis and inflammatory cellular infiltration, (c) carbon tetrachloride-intoxicated rats treated with silymarin alone revealing moderate improvement of hepatic cellular degeneration, (d) carbon tetrachloride-intoxicated rats treated with silymarin and chlorogenic acid showing marked improvement of hepatocellular degeneration but still there are scattered areas of degeneration, (e) carbon tetrachloride-intoxicated rats treated with silymarin and melatonin with few areas of little hepatic cells degeneration and focal areas of cellular infiltration and (f ) carbon tetrachloride-intoxicated rats treated with silymarin, chlorogenic acid, and melatonin showing apparently normal liver tissue

Figure 2: Photomicrographs of H and E-stained liver sections of (a) control rats, (b) carbon tetrachloride-intoxicated rats showing focal areas with massive degeneration, necrosis and inflammatory cellular infiltration, (c) carbon tetrachloride-intoxicated rats treated with silymarin alone revealing moderate improvement of hepatic cellular degeneration, (d) carbon tetrachloride-intoxicated rats treated with silymarin and chlorogenic acid showing marked improvement of hepatocellular degeneration but still there are scattered areas of degeneration, (e) carbon tetrachloride-intoxicated rats treated with silymarin and melatonin with few areas of little hepatic cells degeneration and focal areas of cellular infiltration and (f ) carbon tetrachloride-intoxicated rats treated with silymarin, chlorogenic acid, and melatonin showing apparently normal liver tissue