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  Indian J Med Microbiol
 

Figure 3: (a) Xanthohumol induces early and late apoptosis. From the flow cytometry analysis, the first quadrant (lower left) depicts percentage of viable cells, second quadrant (lower right) depicts percentage of early apoptotic cells, third quadrant (upper right) depicts late apoptotic or secondary necrotic cells and fourth quadrant (upper left) depicts primary necrotic cells. (b) Xanthohumol treatment results in a shift in mitochondrial membrane potential. Viable cells with active mitochondria have high Ψm and form JC-1 aggregates (P5 region). Mitochondria of apoptotic or necrotic cells have low Ψm and JC-1 remains as monomer (P6 region)

Figure 3: (a) Xanthohumol induces early and late apoptosis. From the flow cytometry analysis, the first quadrant (lower left) depicts percentage of viable cells, second quadrant (lower right) depicts percentage of early apoptotic cells, third quadrant (upper right) depicts late apoptotic or secondary necrotic cells and fourth quadrant (upper left) depicts primary necrotic cells. (b) Xanthohumol treatment results in a shift in mitochondrial membrane potential. Viable cells with active mitochondria have high Ψm and form JC-1 aggregates (P5 region). Mitochondria of apoptotic or necrotic cells have low Ψm and JC-1 remains as monomer (P6 region)