Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 17  |  Issue : 74  |  Page : 275--281

Resveratrol exerts anti-inflammatory effect in lipopolysaccharide-induced lung inflammation via downregulation of antioxidant and inflammatory mediators


Xinxin Liang1, Jian Shen1, Xueming Duan1, Rongbing Zhou2, Peng Liu3, Xiaoming CHi4 
1 Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Chengdu, Sichuan Province, China
2 Department of Intensive Medicine, The People's Hospital of Guangrao, Dongying, Shandong Province, China
3 Department of Emergency, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
4 Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, China

Correspondence Address:
Xiaoming CHi
Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, 261031
China

Background: Acute lung inflammation (ALI) is a serious health condition that causes severe pulmonary distress, tissue loss, and ultimately leads to death of the patient. Previously, theantagonisticrole of flavonoids has been extensively studied with respect to inflammation in cancer. Inflammatory reaction targeted during the lung cancer therapy. Aims and Objectives: In this study, the chemoprotective effect of resveratrol and its of mechanism of action against the Lipopolysaccharide (LPS)-induced lung inflammation was investigated. Materials and Methods: In this in vitro study, we performed experiments using RAW 264.7 cells. LPS was used to induce inflammation in the lungs of Swiss Wistar rats that were randomly divided into different groups. The rats were treated with resveratrol in a dose-dependent manner. The lung tissue and dry/wet weight of lung tissue was estimated. The antioxidant activity and anti-inflammatory parameters were also estimated. Results: According to results, resveratrol significantly reduced the secretion of pro-inflammatory cytokines including interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor-α (TNF-α), IL-18, IL-10, and antioxidant parameters viz., glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD), respectively. Resveratrol significantly (P<0.001) reduced the weight of lung tissue and dry/wet of lung tissue at dose-dependent manner. Conclusion: In summary, resveratrol plays the role of a chemo-protective agent against the LPS-induced lung inflammation via anti-inflammatory and antioxidant mechanism.


How to cite this article:
Liang X, Shen J, Duan X, Zhou R, Liu P, CHi X. Resveratrol exerts anti-inflammatory effect in lipopolysaccharide-induced lung inflammation via downregulation of antioxidant and inflammatory mediators.Phcog Mag 2021;17:275-281


How to cite this URL:
Liang X, Shen J, Duan X, Zhou R, Liu P, CHi X. Resveratrol exerts anti-inflammatory effect in lipopolysaccharide-induced lung inflammation via downregulation of antioxidant and inflammatory mediators. Phcog Mag [serial online] 2021 [cited 2022 Dec 1 ];17:275-281
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2021;volume=17;issue=74;spage=275;epage=281;aulast=Liang;type=0