Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 17  |  Issue : 74  |  Page : 263--267

In silico studies on the therapeutic potential of novel marker compounds isolated from chemically modified bioactive fraction from Curcuma longa (Non-carbonyl Curcuma longa)


Arshi Naqvi1, Reem A K. Al-Harbi3, Samah Ali2, Richa Malasoni4, Swati Gupta4, Anil Kumar Dwivedi4 
1 Department of Chemistry, College of Science, Taibah University, Al-Madina Al-Munawwara, Saudi Arabia; Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
2 Department of Chemistry, College of Science, Taibah University, Al-Madina Al-Munawwara, Saudi Arabia; Vitamins, The National Organization for Drug Control and Research, Al-Agouzah, Giza, Egypt

Correspondence Address:
Arshi Naqvi
Pharmaceutics Division, CSIR-Central Drug Research Institute, B1/10 Jankipuram Extension, Sitapur Road, Lucknow - 226 031, Uttar Pradesh

Background: Curcuma longa, a perennial herb, is a member of the Zingiberaceae (ginger) family is described to possess a broad spectrum of biological activities. Herbal medicament (HM) or curcuma oil is a bioactive standardized hexane-soluble fraction of C. longa and is established for its neuroprotective effect. HM was modified chemically to unfasten compounds containing carbonyl group in it resulting in a bioactive non-carbonyl C. longa (NCCL). Objectives: In the present study, novel marker compounds (A and B) have been successfully isolated from NCCL and their various in silico traits and interactions were studied. Materials and Methods: Marker compounds A and B were characterized utilizing various spectroscopic data (one-dimensional [1D]/2D Nuclear Magnetic Resonance (NMR), mass spectrometry, and infrared). Isolated compounds were subjected to in silico computational tools for predicting their drug-likeness, pharmacokinetic, pharmacodynamic properties. Results: Both compounds A and B flaunted drug-like properties by following the standard descriptors along with good in silico absorption. Conclusion: Novel marker compounds A and B were successfully isolated from NCCL and fully characterized utilizing spectroscopic techniques. Both the compounds displayed good drug-like properties.


How to cite this article:
Naqvi A, K. Al-Harbi RA, Ali S, Malasoni R, Gupta S, Dwivedi AK. In silico studies on the therapeutic potential of novel marker compounds isolated from chemically modified bioactive fraction from Curcuma longa (Non-carbonyl Curcuma longa).Phcog Mag 2021;17:263-267


How to cite this URL:
Naqvi A, K. Al-Harbi RA, Ali S, Malasoni R, Gupta S, Dwivedi AK. In silico studies on the therapeutic potential of novel marker compounds isolated from chemically modified bioactive fraction from Curcuma longa (Non-carbonyl Curcuma longa). Phcog Mag [serial online] 2021 [cited 2022 Dec 2 ];17:263-267
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2021;volume=17;issue=74;spage=263;epage=267;aulast=Naqvi;type=0