Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 72  |  Page : 843--850

Antineoplastic potential of eupatilin against benzo[a]pyrene-induced lung carcinogenesis


Yanzhou Han, Zhiqing Zheng, Fanping Liu, Yanqing Tian, Lixin Bi, Sujuan Zhang 
 Department of Tuberculosis, Affiliated Hospital of Hebei University, Baoding City, 071000, China

Correspondence Address:
Lixin Bi
Department of Tuberculosis, Affiliated Hospital of Hebei University, Baoding City
China
Sujuan Zhang
Department of Tuberculosis, Affiliated Hospital of Hebei University, Baoding City
China

Background: Most of the conservative therapies used to treat lung cancer show serious side effects. In addition, the prevalence and death rates due to lung cancer have been increasing alarmingly across the globe. Eupatilin (EUP) is a naturally occurring flavone which is primarily the active ingredient of the traditional Chinese medicine Artemisia asiatica. Materials and Methods: In this study, we evaluated the antineoplastic effect of EUP against benzo(a)pyrene-induced lung cancer in Swiss albino mice. We analyzed the level of xenobiotics, liver dysfunction enzymes (LDEs), pro-inflammatory cytokines, and histology of the liver. Furthermore, we conducted in vitro experiments (A549 cells) to elucidate the amount of cell proliferation, apoptosis, and their markers (caspases 3 and 9). Results: The EUP (30 mg/kg bw) treatment of tumor-bearing mice with EUP revealed the normal levels of xenobiotic, LDEs, antioxidant enzymes, lipid peroxidation in the liver and further carcinoembryonic antigen, pro-inflammatory marker, and histology in lung tissues. EUP inhibited the proliferation of A549 cells and induced the formation of reactive oxygen species and apoptosis by upregulating the expression of caspases 3 and 9. Conclusion: Overall, these results substantiate the anti-neoplastic effects of EUP against carcinogen-induced lung cancer in in vitro and in vivo models.


How to cite this article:
Han Y, Zheng Z, Liu F, Tian Y, Bi L, Zhang S. Antineoplastic potential of eupatilin against benzo[a]pyrene-induced lung carcinogenesis.Phcog Mag 2020;16:843-850


How to cite this URL:
Han Y, Zheng Z, Liu F, Tian Y, Bi L, Zhang S. Antineoplastic potential of eupatilin against benzo[a]pyrene-induced lung carcinogenesis. Phcog Mag [serial online] 2020 [cited 2021 Apr 21 ];16:843-850
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2020;volume=16;issue=72;spage=843;epage=850;aulast=Han;type=0