Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 15  |  Issue : 62  |  Page : 78--83

Exploring the potential of Desmodium gangeticum (L.) DC. extract against spatial memory deficit in rats


Nilanjan Changdar1, Rajesh Kumar Ganjhu2, Samita Rijal1, Ayush Kumar1, Shanchari Basu Mallik1, Madhavan Nampoothiri1, Rekha R Shenoy1, Kiran B Sonawane3, Mallikarjuna C Rao1, Jayesh Mudgal1 
1 Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India
2 Radhika Ayurveda Research and Development, Pune, Maharashtra, India
3 Organic Division, National Chemical Laboratory, Pune, Maharashtra, India

Correspondence Address:
Jayesh Mudgal
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576 104, Karnataka
India

Background: A few published reports demonstrated the neuroprotective effect of Desmodium gangeticum (L.) DC. in an acute model of dementia. Objective: The purpose of the present study was to evaluate the preclinical efficacy of D. gangeticum against chronic dementia when administered prophylactically. Materials and Methods: Chronic spatial memory deficit was induced in rats by aluminum chloride (AlCl3, 10 mg/kg, i.p.). Treatment with hydroalcoholic whole plant extract of D. gangeticum (DG extract) was initiated 2 week before AlCl3 challenge and continued till the 51st day after the challenge, orally at the dose of 400 mg/kg/day. The spatial memory was assessed by Morris water maze test. Hippocampal and frontal cortex acetyl cholinesterase (AChE) and oxidative stress were assessed in diseased rat brains. Results: Chronic administration of AlCl3 produced spatial memory deficit in rats. Memory impairment was manifested in rats as an increase in escape latency and D-quadrant latency whereas a decrease in total time spent in D-quadrant. These behavioral alterations were reversed significantly by the treatment with DG extract. In addition, DG extract significantly increased the island time, indicating memory improvement. DG extract corrected the declined AChE in frontal cortex and altered frontal cortex/hippocampus catalase activity. Phytochemical investigation of the DG extract revealed large content of saponins among the other phytochemicals such as tannins, alkaloids, and flavonoids. Conclusion: These results indicate the possible prophylactic potential of saponin-rich DG extract against chronic memory deficit in rats.


How to cite this article:
Changdar N, Ganjhu RK, Rijal S, Kumar A, Mallik SB, Nampoothiri M, Shenoy RR, Sonawane KB, Rao MC, Mudgal J. Exploring the potential of Desmodium gangeticum (L.) DC. extract against spatial memory deficit in rats.Phcog Mag 2019;15:78-83


How to cite this URL:
Changdar N, Ganjhu RK, Rijal S, Kumar A, Mallik SB, Nampoothiri M, Shenoy RR, Sonawane KB, Rao MC, Mudgal J. Exploring the potential of Desmodium gangeticum (L.) DC. extract against spatial memory deficit in rats. Phcog Mag [serial online] 2019 [cited 2021 Jun 18 ];15:78-83
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2019;volume=15;issue=62;spage=78;epage=83;aulast=Changdar;type=0