Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 15  |  Issue : 62  |  Page : 34--37

In vitro antileishmanial activity of methanolic extracts for some selected medicinal plants


Ahmed Gomaa Gomaa Darwish1, Mamdouh Nabil Samy2, Sachiko Sugimoto4, Katsuyoshi Matsunami4, Hideaki Otsuka3 
1 Department of Biochemistry, Faculty of Agriculture, Minia University, Minia, Egypt; Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
2 Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
3 Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University; Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan

Correspondence Address:
Ahmed Gomaa Gomaa Darwish
Department of Biochemistry, Faculty of Agriculture, Minia University, Minia 61519

Objective: The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants; ten well-known medicinal plants cultivated and growing under African environmental conditions were studied. Materials and Methods: The methanolic extracts of these plants were screened for their antileishmanial activity against Leishmania major using 3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide assay. Results: The methanol extract of Colchicum autumnale and Alpinia officinarum showed potent antileishmanial activity at inhibition% value of 98.29% ± 0.75% and 97.25 ± 1.63%, respectively, while Silybum marianum exhibited inhibition% value of 90.97% ± 1.13%, compared with the standard amphotericin B (89.31% ± 2.08%). Conclusion: Considering these results, medicinal plants from African environment could constitute a developer source for antileishmanial compounds.


How to cite this article:
Gomaa Darwish AG, Samy MN, Sugimoto S, Matsunami K, Otsuka H. In vitro antileishmanial activity of methanolic extracts for some selected medicinal plants.Phcog Mag 2019;15:34-37


How to cite this URL:
Gomaa Darwish AG, Samy MN, Sugimoto S, Matsunami K, Otsuka H. In vitro antileishmanial activity of methanolic extracts for some selected medicinal plants. Phcog Mag [serial online] 2019 [cited 2021 Jun 22 ];15:34-37
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2019;volume=15;issue=62;spage=34;epage=37;aulast=Gomaa;type=0