Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 13  |  Issue : 51  |  Page : 483--487

Decoction of Dictamnus Dasycarpus Turcz. Root bark ameliorates skin lesions and inhibits inflammatory reactions in mice with contact dermatitis


Beodeul Yang1, Hong-Bum Lee1, Sura Kim1, Young Chul Park2, Koanhoi Kim3, Hyungwoo Kim1 
1 Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam, Korea
2 Department of Microbiology and Immunology, School of Medicine, Pusan National University, Gyeongnam, Korea
3 Department of Pharmacology, School of Medicine, Pusan National University, Gyeongnam, Korea

Correspondence Address:
Hyungwoo Kim
Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam
Korea

Background: The root bark of Dictamnus dasycarpus Turcz. (Dictamni Radicis Cortex) has been widely used to treat skin diseases in Korea, and its anti-inflammatory efficacies were recently reported. Objective: The paper aims to investigate the inhibitory effects of decoction of Dictamni Radicis Cortex (DDRC) in mice with contact dermatitis (CD). Materials and Methods: We investigated the effects of DDRC on skin lesion characteristics such as crust, scales, incrustation and petechiae, the erythema and melanin indexes, skin thickness, histopathologic changes, and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced CD mice. Results: Topical application of DDRC ameliorated crust, scales, incrustation, and induced by DNFB. In addition, DDRC lowered the erythema index significantly (P < 0.05). DDRC effectively inhibited enlargement of skin thickness (P < 0.05). Histopathologic observation showed that DDRC inhibited epidermal hyperplasia, hyperkeratosis, and spongiotic changes. Finally, DDRC decreased production levels of IFN-γ, TNF-α and IL-6 induced by repeated application of DNFB (P < 0.05). Conclusion: These data suggest that DDRC can be used in the treatment of inflammatory skin diseases including CD. Moreover, these results are closely related to the decreasing production of TNF-α IFN-γ and IL-6 in inflamed tissues. Abbreviations used: DDRC: decoction of Dictamni Radicis Cortex, CD: contact dermatitis, DNFB: 1-fluoro-2,4-dinitrofluorobenzene, AOO: acetone and olive oil, DEX: dexamethasone, CBA: cytometric bead array


How to cite this article:
Yang B, Lee HB, Kim S, Park YC, Kim K, Kim H. Decoction of Dictamnus Dasycarpus Turcz. Root bark ameliorates skin lesions and inhibits inflammatory reactions in mice with contact dermatitis.Phcog Mag 2017;13:483-487


How to cite this URL:
Yang B, Lee HB, Kim S, Park YC, Kim K, Kim H. Decoction of Dictamnus Dasycarpus Turcz. Root bark ameliorates skin lesions and inhibits inflammatory reactions in mice with contact dermatitis. Phcog Mag [serial online] 2017 [cited 2021 Feb 28 ];13:483-487
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2017;volume=13;issue=51;spage=483;epage=487;aulast=Yang;type=0