Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 13  |  Issue : 51  |  Page : 430--438

Intervention effects of atorvastatin combined with Panax notoginseng saponins on rats with atherosclerosis complicated with hepatic injury


Qing-Fang Jiang1, Min-Yi Huang2, Kang-Yuan Wu3, Jie-Ling Weng4, Rong-Gui Deng1, Xin-Jie Xu5, Jian-Pei Xu1, Tao Jiang1 
1 Department of Pharmacy, West Hospital District, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510280, China
2 Department of Pharmacy, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, China
3 Department of Hygienic Toxicology, School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
4 Department of Pathology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, China
5 Drug Research Centre, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China

Correspondence Address:
Tao Jiang
The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang East Road, Haizhu District, Guangzhou, Guangdong 510280
China

Background: Statins cannot be used for some active liver diseases, which limits its application to some extent. The combined use of statins with other drugs may be one of the ways to solve this dilemma. Objective: This research aims to evaluate the effects of atorvastatin combined with Panax notoginseng saponins (PNS) on rats with atherosclerosis (AS) complicated with hepatic injury. Materials and Methods: Seventy-two male Wistar rats were randomly categorized into control group (without any intervention, Group A) and AS model groups, which were divided into hepatic injury (Groups B–E) and nonhepatic injury (Groups F–I) groups. Hepatic and nonhepatic injury groups were intragastrically treated with 5.5 mg/kg·d atorvastatin (Group B, F), 200 mg/kg·d PNS (Group C, G), 5.5 mg/kg·d atorvastatin + 200 mg/kg·d PNS (Group D, H), and normal saline (Group E, I). After 8 weeks, total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol, low density lipoprotein-cholesterol (LDL-C), and serum calcium were analyzed to evaluate the hypolipidemic effect. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, total bilirubin, and r-glutamyltransferase levels were measured to assess liver function. The thoracic aortas were used for hematoxylin–eosin staining. Results: In both hepatic injury and nonhepatic injury groups, TC, TG and LDL-C levels significantly decreased in Groups B, D, F, and H. ALT and AST levels significantly increased in Group B, but significantly decreased in Groups C and D. The aortic intima thickness was significantly lower in Groups B, D, F, and H than that in the normal saline group. Conclusion: The combination of atorvastatin and PNS treatment showed a significant hypolipidemic effect and hepatic enzyme stability function. Abbreviations used: PNS: Panax notoginseng saponins; AS: Atherosclerosis; TC: Total cholesterol; TG: Triglyceride; HDL-C: High density lipoprotein-cholesterol; LDL-C: Low density lipoprotein-cholesterol; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; T-BIL: Total bilirubin; r-GT: R-glutamyltransferase; HE: Hematoxylin–eosin.


How to cite this article:
Jiang QF, Huang MY, Wu KY, Weng JL, Deng RG, Xu XJ, Xu JP, Jiang T. Intervention effects of atorvastatin combined with Panax notoginseng saponins on rats with atherosclerosis complicated with hepatic injury.Phcog Mag 2017;13:430-438


How to cite this URL:
Jiang QF, Huang MY, Wu KY, Weng JL, Deng RG, Xu XJ, Xu JP, Jiang T. Intervention effects of atorvastatin combined with Panax notoginseng saponins on rats with atherosclerosis complicated with hepatic injury. Phcog Mag [serial online] 2017 [cited 2022 Jan 23 ];13:430-438
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2017;volume=13;issue=51;spage=430;epage=438;aulast=Jiang;type=0