Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 13  |  Issue : 51  |  Page : 385--392

Ethanolic fraction of Terminalia tomentosa attenuates biochemical and physiological derangements in diet induced obese rat model by regulating key lipid metabolizing enzymes and adipokines


Balaji Meriga1, Parim Brahma Naidu1, Ganjayi Muniswamy1, GEN Hanuma Kumar1, Ramavat Ravindar Naik2, Suresh Pothani2 
1 Animal Physiology and Biochemistry Laboratory, Department of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India
2 National Center for Laboratory Animal Sciences, National Institute of Nutrition, Hyderabad, India

Correspondence Address:
Balaji Meriga
Department of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh
India

The prevalence of overweight-obesity and associated comorbidities have reached alarming levels necessitating the need to explore effective therapeutics. In the present work, we demonstrated the promising antiobesity activity of ethanolic fraction of Terminalia tomentosa bark (EFTT) in diet induced obese rat model. High Fat Diet (HFD)-fed obese rats were orally administered with EFTT (50, 100 and 200 mg/kg body weight). Changes in body weight, body composition, bone mineral concentration, bone mineral density, plasma glucose, insulin, leptin, adiponectin, circulatory and tissue lipid profiles, and the activities of liver antioxidant enzymes, key lipid metabolic enzymes and mRNA expressions of fatty acid synthase (FAS), peroxisome proliferator-activated receptor gamma (PPAR-γ), leptin and tumor necrosis factor alpha (TNF-α) were assessed in experimental rats in the presence and absence of EFTT. At a dose of 200 mg/kg b.wt, EFTT has substantially attenuated body weight and related patho-physiological alterations in HFD-induced obese rats. These findings were correlated with histological observations of adipose tissue. The therapeutic activity of EFTT could be possibly through restoration of antioxidants status, regulation of key lipid metabolizing enzymes, expression of FAS, leptin, PPAR-γ and by synchronized control of energy metabolism in liver and adipose tissue.


How to cite this article:
Meriga B, Naidu PB, Muniswamy G, Kumar GH, Naik RR, Pothani S. Ethanolic fraction of Terminalia tomentosa attenuates biochemical and physiological derangements in diet induced obese rat model by regulating key lipid metabolizing enzymes and adipokines.Phcog Mag 2017;13:385-392


How to cite this URL:
Meriga B, Naidu PB, Muniswamy G, Kumar GH, Naik RR, Pothani S. Ethanolic fraction of Terminalia tomentosa attenuates biochemical and physiological derangements in diet induced obese rat model by regulating key lipid metabolizing enzymes and adipokines. Phcog Mag [serial online] 2017 [cited 2022 Jan 22 ];13:385-392
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2017;volume=13;issue=51;spage=385;epage=392;aulast=Meriga;type=0