Year : 2017 | Volume
: 13 | Issue : 50 | Page : 262--265
Immunomodulatory, cytotoxicity, and antioxidant activities of roots of Ziziphus mauritiana
Samina Afzal1, Murium Batool2, Bashir Ahmad Ch1, Ashfaq Ahmad3, Muhammad Uzair1, Khurram Afzal3
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
2 Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
3 Department of Physiology and Pharmacology, Universiti Sains Malaysia, 11800 Penang, Malaysia
Aims: The study is conducted to evaluate the immunomodulatory, cytotoxicity, and antioxidant potential of Ziziphus mauritiana (Rhamnaceae). Phytochemical analysis of Z. mauritiana revealed the presence of alkaloids, anthraquinone glycoside, cardiac glycoside, saponin, tannin, and flavonoids. Methodology: The cytotoxicity of the plant Z. mauritiana was evaluated by brine shrimp lethality test. Antioxidant parameters such as superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) levels were calculated in the plasma of rats after chronic administration of 400 mg/kg of Z. mauritiana for 6 weeks. Results: The dichloromethane extract of the plant exhibited significant immunomodulatory activity, with inhibitory concentration 50% of 55.43 ± 7.9. The dichloromethane extracts of the plant showed 70% mortality at concentration 1000 μg/ml. SOD and T-AOC levels were increased while MDA level in the plasma was reduced in the plasma of rats treated with dichloromethane Z. mauritiana. Conclusion: This can be deduced that the root of Z. mauritiana has immunomodulatory, cytotoxic, and antioxidant potential.
Abbreviations used: SOD: Superoxide dismutase; T-AOC: Total antioxidant capacity; MDA: Malondialdehyde; ZMRD: Z. mauritiana root extract of dichloromethane fraction; LD50: Z. mauritiana root extract of methanol fraction ZMRM, lethal dose 50.
Faculty of Pharmacy, Bahauddin Zakariya University, Multan
|How to cite this article:|
Afzal S, Batool M, Ch BA, Ahmad A, Uzair M, Afzal K. Immunomodulatory, cytotoxicity, and antioxidant activities of roots of Ziziphus mauritiana.Phcog Mag 2017;13:262-265
|How to cite this URL:|
Afzal S, Batool M, Ch BA, Ahmad A, Uzair M, Afzal K. Immunomodulatory, cytotoxicity, and antioxidant activities of roots of Ziziphus mauritiana. Phcog Mag [serial online] 2017 [cited 2021 Dec 4 ];13:262-265
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2017;volume=13;issue=50;spage=262;epage=265;aulast=Afzal;type=0