Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 12  |  Issue : 46  |  Page : 228--230

Life span and motility effects of ethanolic extracts from Sophora moorcroftiana seeds on Caenorhabditis elegans


Xin Li1, Junxian Han1, Rongyan Zhu1, Rongrong Cui1, Xingming Ma2, Kaizhong Dong3 
1 Department of Immunology, School of Basic Medical Sciences, Lanzhou 730000, China
2 Department of Immunology, School of Basic Medical Sciences; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou 730000, China
3 Department of Microbiology, Medical College, Northwest University for Nationalities, Lanzhou 730000, China

Correspondence Address:
Kaizhong Dong
Department of Microbiology, Medical College, Northwest University for Nationalities, Lanzhou 730000
China
Xingming Ma
Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000
China

Background: Sophora moorcroftiana is an endemic shrub species with a great value in folk medicine in Tibet, China. In this study, relatively little is known about whether S. moorcroftiana is beneficial in animals' nervous system and life span or not. Materials and Methods: To address this question, under survival normal temperature (25°C), S. moorcroftiana seeds were extracted with 95% ethanol, and Caenorhabditis elegans were exposed to three different extract concentrations (100 mg/L, 200 mg/L, and 400 mg/mL) from S. moorcroftiana seeds. Results: The 95% ethanolic extracts from S. moorcroftiana seeds could increase life span and slow aging-related increase in C. elegans and could not obviously influence the motility of C. elegans. Conclusion: Given these results by our experiment for life span and motility with 95% ethanolic extracts from S. moorcroftiana seeds in C. elegans, the question whether S. moorcroftiana acts as an anti-aging substance in vivo arises. SUMMARY
  • The 95% ethanolic extracts from S. moorcroftiana seeds have no effect on the life span in C. elegans when extract concentrations from S. moorcroftiana seeds <400 mg/L
  • The 400 mg/L 95% ethanolic extracts from S. moorcroftiana seeds could increase life span in C. elegans
  • The 95% ethanolic extracts from S. moorcroftiana seeds could not obviously influence the motility in C. elegans.
Abbreviation used: S. moorcroftiana: Sophora moorcroftiana; C. elegan: Caenorhabditis elegan; E. coli OP50: Escherichia coli OP50; DMSO: Dimethyl sulfoxide.



How to cite this article:
Li X, Han J, Zhu R, Cui R, Ma X, Dong K. Life span and motility effects of ethanolic extracts from Sophora moorcroftiana seeds on Caenorhabditis elegans.Phcog Mag 2016;12:228-230


How to cite this URL:
Li X, Han J, Zhu R, Cui R, Ma X, Dong K. Life span and motility effects of ethanolic extracts from Sophora moorcroftiana seeds on Caenorhabditis elegans. Phcog Mag [serial online] 2016 [cited 2022 Aug 7 ];12:228-230
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2016;volume=12;issue=46;spage=228;epage=230;aulast=Li;type=0