Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 12  |  Issue : 45  |  Page : 27--31

Potential antidepressant constituents of Nigella sativa seeds


Ehab S Elkhayat1, Mohammad S Alorainy2, Ibrahim M El-Ashmawy3, Shawkat Fat'hi4 
1 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
2 Department of Pharmacology, College of Medicine, Qassim University, Buraidah, AL-Qassim, Saudi Arabia
3 Department of Pharmacology, Faculty of Veterinary Medicine, Alexandria University, Egypt; Department of Veterinary Medicine, College of Agricultural and Veterinary Medicine, Qassim University, Buraidah, AL-Qassim, Saudi Arabia
4 Department of Pharmacology, Faculty of Veterinary Medicine, Alexandria University; Department of Food Hygiene, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt

Correspondence Address:
Ehab S Elkhayat
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524
Egypt

Background: Nigella sativa Linn. is well known seed in the Middle East, Asia, and the Far East as a natural remedy for many ailments and as a flavoring agent proclaimed medicinal usage dating back to the ancient Egyptians, Greeks, and Romans. An authentic saying of the Prophet Muhammad (Peace Be Upon Him) about black seed is also quoted in Al-Bukhari. Objective: This study was carried out to evaluate the antidepressant effect and isolate the potential antidepressant constituents of the polar extract of N. sativa seeds. Materials and Methods: The antidepressant effect was evaluated through the immobility duration in tail suspension and forced swim tests (FSTs). Albino mice were orally treated with N. sativa polar extract and its RP-18 column chromatography fractions (50 and 100 mg/kg,). Results: The polar extract and two of its sub-fractions were significantly able to decrease the immobility time of mice when subjected to both tail suspension and FSTs, the effects are comparable to standard drug (Sertraline, 5 mg/kg). However, these treatments did not affect the number of crossings and rearing in the open field test. Phytochemical investigation of the two active fractions led to the isolation of quercetin-3-O-α-L-rhamnopyranoside 1, quercetin-7-O-β-D-gluco- pyranoside 2, tauroside E 3, and sapindoside B as the potential antidepressant constituents.


How to cite this article:
Elkhayat ES, Alorainy MS, El-Ashmawy IM, Fat'hi S. Potential antidepressant constituents of Nigella sativa seeds.Phcog Mag 2016;12:27-31


How to cite this URL:
Elkhayat ES, Alorainy MS, El-Ashmawy IM, Fat'hi S. Potential antidepressant constituents of Nigella sativa seeds. Phcog Mag [serial online] 2016 [cited 2022 Aug 19 ];12:27-31
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2016;volume=12;issue=45;spage=27;epage=31;aulast=Elkhayat;type=0