Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 11  |  Issue : 44  |  Page : 545--549

Hypoglycemic effects of a standardized extract of salvia miltiorrhiza roots in rats


Mauro A. M. Carai1, Giancarlo Colombo2, Barbara Loi2, Alessandro Zaru2, Antonella Riva3, Walter Cabri3, Paolo Morazzoni3 
1 Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato (CA); Cagliari Pharmacological Research S.R.L., Cagliari (CA), Italy
2 Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato (CA), Italy
3 Indena S.p.A, Milan (MI), Italy

Correspondence Address:
Giancarlo Colombo
Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato (CA)
Italy

Background and Aims: Salvia miltiorrhiza Bunge (Labiatae) is a Chinese medicinal plant, the dried roots of which (known as Dan-Shen) have been used for hundreds of years in the treatment of a series of ailments, including hyperglycemia. This study was designed to evaluate the hypoglycemic effect of a new, standardized extract of S. miltiorrhiza. Materials and Methods: S. miltiorrhiza extract (containing 21% total tanshinones and 3.7% tanshinone IIA) was administered acutely and intragastrically at the doses of 0, 50, 100, and 200 mg/kg to male, healthy, fasted Wistar rats 60 min before the intragastric infusion of a bolus of starch (3 g/kg; a semi-naturalistic experimental condition) (Experiment 1) or glucose (2 g/kg) (Experiment 2). Results: In both experiments, treatment with S. miltiorrhiza extract produced a dose-related decrease in glycemia, evidenced in terms of reduction of peak value and/or area under the curve of the time-course of glycemia. The effect of S. miltiorrhiza extract occurred at doses devoid of any behavioral toxicity in rats. Conclusion: The results of this study suggest that the hypoglycemic effect of S. miltiorrhiza extract was likely secondary to an action on carbohydrate metabolism. These results are consistent with several preclinical and clinical data and add further support to the hypothesis that S. miltiorrhiza extracts may act as effective anti-hyperglycemic remedies.


How to cite this article:
Carai MA, Colombo G, Loi B, Zaru A, Riva A, Cabri W, Morazzoni P. Hypoglycemic effects of a standardized extract of salvia miltiorrhiza roots in rats .Phcog Mag 2015;11:545-549


How to cite this URL:
Carai MA, Colombo G, Loi B, Zaru A, Riva A, Cabri W, Morazzoni P. Hypoglycemic effects of a standardized extract of salvia miltiorrhiza roots in rats . Phcog Mag [serial online] 2015 [cited 2021 Nov 29 ];11:545-549
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=44;spage=545;epage=549;aulast=Carai;type=0