Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 11  |  Issue : 44  |  Page : 496--500

Modulatory role of Shorea robusta bark on Glucose-metabolizing enzymes in diethylnitrosamine induced hepatocellular carcinoma in rats


A Kalaiselvan1, T Anand2, K Gokulakrishnan2, MC Kamaraj1, S Velavan3 
1 Centre for Research and Development, Marudupandiyar College, Thanjavur, Tamil Nadu, India
2 Department of Chemistry, PRIST University, Thanjavur, Tamil Nadu, India
3 Department of Biochemistry, Marudupandiyar College, Thanjavur, Tamil Nadu, India

Correspondence Address:
A Kalaiselvan
Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu
India

Introduction: The modulations of glucose-metabolizing enzyme activities play a vital rolein the depletion of energy metabolism and leads to inhibition of cancer growth. Objective: To find the effect of shorearobusta bark extract on glucose-metbolizing enzymes in diethylnitrosamine (DEN) induced hepatocellular carcinoma rats. Materials and Methods: Biochemical evaluation of glucose metabolizing enzyme were done in before and after shorearobusta bark extract (500mg/kg) treatment in DEN induced rats. Results: A significant increasein the activities of the key glycolytic enzymes viz., hexokinase and phosphoglucoisomerase, with a significant decrease in the gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatasewere observed in HCC bearing rats, when compared with the control. Administration of shorearobusta extract caused a significant decrease in theactivities of glycolytic enzymes and an increase in the gluconeogenic enzymes activities to near normal values. Conclusion: The current findings suggest that the S. robusta extract has a definite modulating role on the key enzymes ofglucose-metabolism in HCC. The modulatory effect may be due to the phytoactive constituents present in the extract of S. robusta.


How to cite this article:
Kalaiselvan A, Anand T, Gokulakrishnan K, Kamaraj M C, Velavan S. Modulatory role of Shorea robusta bark on Glucose-metabolizing enzymes in diethylnitrosamine induced hepatocellular carcinoma in rats.Phcog Mag 2015;11:496-500


How to cite this URL:
Kalaiselvan A, Anand T, Gokulakrishnan K, Kamaraj M C, Velavan S. Modulatory role of Shorea robusta bark on Glucose-metabolizing enzymes in diethylnitrosamine induced hepatocellular carcinoma in rats. Phcog Mag [serial online] 2015 [cited 2021 Dec 8 ];11:496-500
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=44;spage=496;epage=500;aulast=Kalaiselvan;type=0